I usually throw a bit towards things like Comic Relief and Hurricane/Tsunami Appeals. I know that these events are well publicised and other charities could probably do with the donations more, but I don't think I'm alone in doing it.
My wife and I donate money each year to a special charity which helps orphans with AIDS in Thailand. My wife is from Thailand so it seemed like a great charity to give money to on a regular base.
I try to donate to the ROnald McDonald house because I had a loved one that had cancer, and his family was allowed to stay in theRonald McDonald house during his treatments.
I haven't recalled the last time i donated to a charity but i do know that i often donate to the salvation army and helped those affected by hurricanes, i guess i should also try to help the various AIDS organizations out there,
My Church - they help the community. Also donated $10 to that American Idol Charity - it was on TV recently. Wish I could give more, especially to help children.